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Title: Investigation on Interplay of GSK 3 β Signaling Associated with Myocardial Infarction
Researcher: Kumar, Arun
Guide(s): Rajput, Satyendra K and Thanikachalam, Punniyakoti V
Keywords: Clinical Pre Clinical and Health
GSK 3 and#946;
Myocardial Infarction
Pharmacology and Pharmacy
Pharmacology and Toxicology
University: Amity University, Noida
Completed Date: 2017
Abstract: Current study involves the synthesis and investigation of low-dose copper nanoparticles (CuNP) against diabetes mellitus (Streptozotocin, 50 mg/kg, i.p., once) and -induced experimental micro (nephropathy) and macro-vascular (cardio and endothelium) complications. Diabetes mellitus (DM) -induced vascular abnormalities was revealed by reduction in acetylcholine-induced endothelium-dependent relaxation, decrease in aortic and serum nitrite/nitrate concentration, increased CKMB, LDH, SGOT/SGPT, serum creatinine, blood urea nitrogen, induction of proteinuria and oxidative stress. However, treatment with low-dose CuNP (1 mg/kg, p.o. 4 weeks) after streptozotocin administration reduced serum glucose concentration. Moreover, CuNP had shown partial but significant prevention of cardio-vascular structural and functional abnormalities in diabetic rats. Increased bioavailability of NO in endothelium and reduction in oxidative stress might be the possible mechanism involved for protective role of CuNP against diabetes induced micro and macro complications. newline newline
Appears in Departments:Amity Institute of Pharmacy

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02_certificate.pdf143.84 kBAdobe PDFView/Open
03_preliminary pages.pdf586.92 kBAdobe PDFView/Open
04_chapter 1.pdf296.1 kBAdobe PDFView/Open
05_chapter 2.pdf1.18 MBAdobe PDFView/Open
06_chapter 3.pdf72.42 kBAdobe PDFView/Open
07_chapter 4.pdf1.97 MBAdobe PDFView/Open
08_chapter 5.pdf652.08 kBAdobe PDFView/Open
09_chapter 6.pdf957.38 kBAdobe PDFView/Open
10_chapter 7.pdf171.05 kBAdobe PDFView/Open
11_chapter 8.pdf81.22 kBAdobe PDFView/Open
80_recommendation.pdf105.94 kBAdobe PDFView/Open
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