Use of Task Specific Ionic Liquids in the Chemical Transformation and Synthesis of Novel Heterocycles

Abstract

The thesis entitled Use of Task Specific Ionic Liquids in the Chemical Transformation newlineand Synthesis of Novel Heterocycles deals with the uses of task specific ionic liquids newlinewith special properties for chemical transformation and synthesis of heterocyclic newlinecompounds. These task specific ionic liquids further have been used as catalysts in newlineheterocyclic synthesis. The thesis is divided into five chapters. newlineThe first chapter of thesis describes a literature overview of synthesis of task specific newlineionic liquids and their applications in heterocyclic synthesis. In this chapter recent newlineliterature reviews are analyzed for the use of task specific ionic liquid as catalyst in newlinechemical transformation and synthesis of numerous heterocyclic compound having newlinebiological and medicinal properties. newlineThe second chapter of the thesis describes synthesis and applications of novel task newlinespecific ionic liquid Bis[ctmim]Cl- in pharmacologically active compound newlinebenzimidazole.The chapter is divided in two parts. In part-A, carboxylic acid newlinefunctionalized ionic liquid has been synthesized using green methodology and its newlinecharacterization is takes place by means of 1HNMR, Mass, IR spectroscopy. Using this newlineanalysis the it is confirmed that novel TSIL Bis[ctmim]Cl- was synthesized in high (97- newline98%) yields with excellent purity (gt 95%), by eradicating chromatographic purification. newlineIn part-B, use of synthesized novel TSIL Bis[ctmim]Cl- as acidic catalyst has been newlineanalyzed for the synthesis of benzimidazoles using various aldehydes and ophenylenediamine newlineas reagents under solvent free condition. It is observed that newlineBis[ctmim]Cl- provides its H+ ions to aldehydes and OPD to carry out reaction within newlineminimum amount of time and high yields of products. Also same catalyst is reused to newlinecarry out further reactions without affecting its catalytic activity was observed. newlineVII newlineThe third chapter of the thesis describes use of Bis[ctmim]Cl- for the synthesis of newlinetetrasubstituted imidazole and its catalytic ability and superiority over conventional acidic newlinecatalysts in