Ultrasound assisted green synthesis of iron oxide fe zn bimetallic nanoparticles and their applications

Abstract

Nanotechnology is defined as the handling of particle size ranging from 1 to 100 nm.Nanoparticles have gained importance in different areas of research owing to their different properties. The size, shape, morphology and crystallinity determine the nature and characteristics of the nanoparticle compared to their bulk material, which imparts new developments in the field of biomedicine and biosensors. In recent times, biologically synthesized nanoparticles are in demand than the chemically synthesized nanoparticles, since the biosynthesis method restricts the usage of noxious and unsafe substances. Utilizing the bio sources for the synthesis of nanoparticles seems to be a viable, low-cost and environmental-friendly approach. Hence this research work is focused on the green synthesis of iron oxide nanoparticle and Fe/Zn bimetallic nanoparticle using Coriandrumsativum leaf extract. In order to make the synthesis process more successful, it was combined with ultrasonication. The characterization of the nanoparticle synthesized was carried out by UV Vis spectroscopy, X-Ray Diffraction Analysis (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X Ray Analyzer (EDX) and Fourier Transform Infrared Spectroscopy (FTIR). The experimental operating parameters such as time, temperature, ferric chloride concentration and stirring speed for the yield of nano particles were optimized. Using this laboratory data, an Artificial Neural Network (ANN) model has been used to determine the yield of iron oxide nano particle. The neural network configuration of one hidden layer with six neurons (4-6-1) matches well with the experimental values. The synthesized iron oxide nanoparticle and Fe/Zn bimetallic nanoparticles are used for biomedical applications. Hence, the present study is focused on invitroanti microbial, anti oxidant, anti inflammatory, anti diabetic and anti cancer activity of the prepared materials. Iron oxide nanoparticle prepared by stirring method showed maximum zone of inhibition of 16mm and 15mm against the bacterial pathogens, maximum scavenging activity of 63% newline