Study of polyherbal extract loaded pcl nanofibrous mat for the treatment of wound

Abstract

Recent technological development in the field of biomedicines is due to the combination of traditional system of medicine and nanotechnology. Specifically, the nanofibre technology helps in the development of natural drug loaded nanofibrous membrane for wound dressing applications. The drug discovery and wound dressing development is continuous due to the problems associated with the wound healing process. The primary choice of wound treatment in the current scenario is the use of antiseptics and antibiotics as topical and systemic medicine to control and prevent the wound from infection. However, toxicity and the development of antibiotic resistance are considered as drawbacks of antiseptics and antibiotics. People searching for alternative medicine have started using traditional and complementary system of medicines like Siddha and Ayurveda. The natural products specifically medicinal plants or plant parts are the main source of traditional medicine because of easy availability, accessibility, processability and non-toxicity. The plants are used either as monoherbals or polyherbals based on the severity of diseases. The polyherbals are advantageous than monoherbals due to synergistic action and enhancement of phytopharmacological activity from different plants. However, the traditional system of medicines has also failed due to lack of standardization of drugs. In addition, these drugs are applied directly on the wound without considering the concentration of drug. Hence, it is important to standardize the drug and to control the drug release at the target site. Wound dressing materials are used to carry and release the drug to the target site. In recent years, natural or synthetic polymers are used to produce wound dressing material due to its biodegradable and biocompatible nature. However, synthetic polymers are highly used because of its solubility an flexibility. Hence, this study focuses on the development of polyherbal extract loaded Polycaprolactone (PCL) nanofibrous mat using electrospinning technique and is used in the treatment of wound. The polyherbal extract was prepared from the combination of triphala and monoherbals like Acacia catechu, Azadirachta indica, Coscinium fenestratum and Glycyrrhiza glabra. The triphala is used as the main source of antioxidant in this study. Further, the monoherbals were added to enhance the medicinal property and to reduce the toxicity of triphala. newline