Biochemical and Genetic Studies in Women with Recurrent Pregnancy Loss

Abstract

Recurrent Pregnancy Loss (RPL), otherwise called recurrent miscarriage (RM), is a frustrating condition affecting around 2-6% of infertile couple and 12-15% of all pregnancies. The foremost aim of the current study was to assess the various biochemical variables and genetic studies among women with RPL and to envisage the potential risk of various cardiovascular diseases (CVDs) by linking the extent of DNA damage along with the association/concentration of new biomarkers such as Serum Amyloid A (SAA) and Pentraxin (PTX-3). The magnitude of Oxidative Stress (OS) and somatic DNA impairment were assessed. An attempt was also made to identify the role and efficacy of SAA and PTX-3 to predict CVD events and future pregnancy loss. The present study included two hundred and twenty clinically proven women with RPL and one hundred and ten age-matched healthy subjects. The study demonstrated a positive correlation among subjects with recurrent abortion to various demographic, physiological, lifestyle and clinical characteristics. A positive correlation with RPL and the magnitude of somatic DNA damages were also observed. SAA and PTX-3 were found to be valuable biomarkers for the early prediction of CVD risk among women with RPL. This is the first study to demonstrate such an association in RPL subjects. The extent of OS and DNA damage revealed profound role in predicting future PL and CVD events. Changes in lifestyle such as food habit, regular exercise, weight management, reducing psychological stress are the best treatment options for a better reproductive health.