Comparison of Safety Profile of Atypical Antipsychotics Using Signal Detection Techniques and Formulation of Guidelines for Time Response in Schizophrenic Patients

Abstract

The treatment outcomes of existing pharmacotherapeutic strategies of schizophrenia are hindered due to delay in prediction of drug response. Capturing early symptom improvement is a crucial factor in deciding an appropriate and precise therapeutic regimen in schizophrenic patients. In this context, this study was designed to develop a guideline to identify early symptom improvement threshold that can best predict the subsequent response at week 8 in first episode schizophrenia patients alongside generating the safety signals pertinent to atypical antipsychotics. The research findings of this study may aid in unveiling the non-responders of a particular regimen and prevent inappropriate therapy and associated adverse reactions.