Effect of hydro alcoholic extract of Terminalia arjuna bark and Arjunarishta in Inflammatory bowel disease

Abstract

ABSTRACT newlineBackground: newline Terminalia arjuna Roxb. (Combretaceae) a medicinal plant and its formulation newlineArjunarishta, are traditionally utilized in cardiovascular diseases. According to newlineAyurveda, it stabilizes the three doshas - Vata, Pitta and Kapha. This bark possesses newlineanti-inflammatory, antibacterial, antidiarrheal and antioxidant properties which would newlinebe useful for the treatment of inflammatory bowel disease (IBD), which is associated newlinewith bacterial microflora dysbiosis, oxidative stress, inflammatory response activation newlineand immune dysfunction. With the rising disease burden, research should also focus newlineon developing low-cost therapies which would not only help the patients in India but newlinealso in entire Asia, which like India are experiencing a rise in IBD disease burden newlinealong with scarce resources to tackle this problem. newline Phytochemicals like gallic acid, ellagic acid and quercetin, present in newlineTerminalia arjuna bark have exhibited protective effects in rat colitis models. Thus, newlinethis study evaluates the effect of hydro-alcoholic extract of Terminalia arjuna bark newline(TAHA) and Arjunarishta against IBD. newline newlineStudy Objectives newline To study the effect of hydro-alcoholic extract of Terminalia arjuna and newlineArjunarishta on IBD related microbes, colorectal adenocarcinoma cells and TNBS newlineinduced inflammatory bowel disease in rats. newline