Identification and Isolation of Bio Active Constituents from aerial parts of Gomphrena globosa for Cancer Therapy

Abstract

Cancer is a group of diseases characterized by uncontrolled division of cells in the part of the body and is able to invade to other tissues or parts of the body through blood and lymph system. Cancer is of different types that based on the organ or type of cell in which they start. Different cancer types like cancer of lung, esophagus, stomach, oral, pharynx, colon and skin, are affecting the human population. In the developed world, cancer is the leading cause of death whereas in the developing world it is the second leading cause of death as evidenced by the projected number of new cases and death worldwide. The present study aimed to investigate the plants Celosia cristata and Gomphrena globosa, for anticancer property by invitro method and select the best plant with potent antitumor property and investigate the plant in detail. Two plants, Celosia cristata and Gomphrena globosa, were initially studied for anticancer activity by in-vitro method against DLA and ECA cell lines. The Chloroform extract of Gomphrena globosa was found to be with potential cytotoxic activity. The CEGG was further screened in detail for anticancer activity against in-vitro human cell lines and in-vivo DLA and ECA cell lines. The compound possessing potent anticancer activity against human cell lines MCF 7, DU 145, Hela and A-431 was isolated and structurally elucidated by TLC, IR, 1H NMR, 13C NMR, and LC-MS spectral data. The isolated compound Oleuropein was found to possess anticancer activity through antioxidant, antiradical and cell apoptosis mechanism. In Conclusion, the results of the study demonstrated that the plant, Gomphrena globosa possess anticancer activity and the compound responsible for this activity was found to be Oleuropein. The results of the present study on the plant Gomphrena globosa and its isolated compound, Oleuropein clearly showed their potential anti cancer property against breast cancer, prostate cancer, cervical cancer and skin cancer. newline