Identification of Potent Centrally Acting Ligands for Orthosteric and Allosteric Sites of Metabotropic Glutamate Receptor 5 Using Bioinformatics Approaches

Abstract

Neurological disorders affect as many as a billion people across the globe. The causes of newlinemost of the brain disorders are unknown. The existence of these disorders is on an ascending newlinescale during the last 25 years. The G-protein coupled receptors (GPCR) form a major group of newlinetargets for centrally acting drugs. Hailing from the class C of GPCR, the metabotropic newlineglutamate receptors (mGluR) can be divided into eight subtypes. The metabotropic glutamate newlinereceptors (mGluRs) exhibit a slow and steady action upon activation by glutamate. The newlinemGluR5 is grouped in the first category of mGluR along with mGluR1 newline