Synthesis and Anti cancer Activity of Some Novel Benzimidazole Nanoparticles

Abstract

The thesis entitled SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NOVEL BENZIMIDAZOLE NANOPARTICLES dealswith the rate of colorectal cancer incidence is increasing alarmingly in economically transitioning countries. The high mortality rate countries may reflect the adoption of western lifestyle, food behaviour and physical inactivity. The increased death rate added to the huge proportion of colorectal cancer patients in advanced or incurable stage shows that treatment is not possible. Many countries undergo rapid lifestyle changes that will determine its future disease burden. The incidence of colorectal cancer is much lower in India and South Asian countries than in Western countries. Consumption of typical vegetarian diet and the regular use of spices may be one of the reasons for the low incidence. The clinical achievement of related platinum based drugs like cisplatin, as anti-cancer agents constitutes the most incredible contribution to the use of metals in medicine. However most important problems related with these mettalo-drugs include severe toxicity and other side-effects, and main trouble associated with resistant. The subsequently most used classes of chemotherapeutic agents in cancer therapy include molecules that interfere with intercalators or DNA alkylating agents, DNA, like groove binders. However, the activity of various anticancer agents is anchored in intercalation, but specificity could be increased by addition of definite moiety or substituents on the intercalative aromatic core and the classical antitumor agents that they need an active transport mechanism to enter the cancer cells. This is a major drawback to reach adequate concentration of drug inside the cells. In-vivo anticancer activities results revealed that the presence substituted benzimidazole derivative nanoparticle (BZI 3 nano) could have the anticancer potential of the scaffold and selective, good target for drug discovery, which can be regarded as promising anticancer potential.