Discrimination of cancer from Normal subjects a study on the Characterization of urinary Metabolites using native Fluorescence spectroscopy

Abstract

Cancer is a dreaded disease and one of the leading causes of death newlineWorldwide The complete treatment of cancer is possible only when it is newlinedetected at its early stage The life span and also the quality of life are better newlinewhen the disease is detected and treated early The conventional diagnostic newlinetechniques are invasive expensive and some of them are tedious newlineIn this context fluorescence spectroscopy has emerged as a newlinepotential diagnostic tool in particular in the field of diagnostic oncology newlineNative fluorescence spectroscopy of tissues and body bio fluids with real time newlineevaluation is considered as one of the most sensitive methods for monitoring newlineminor changes in the structure and microenvironment of the native newlinefluorophores and hence in the discrimination of tumors Differences in the newlinenative fluorescence have been ascribed to various molecules such as newlinetryptophan Trp tyrosine Tyr phenylalanine Phe indoxyl sulphate newlinereduced form of nicotinamide adenine dinucleotide NADH riboflavin newlinecollagen elastin endogeneous porphyrins pteridines and its derivatives newline newline