Design and Evaluation of Chronopharmaceutical Drug Delivery System for Asthma

Abstract

The main objective of the study described was to develop a time controlled release formulation based on a press coating technique. The intention is that the formulation should be administered in the evening at 10:00 PM in treating diseases in which symptoms are experienced in the early morning hours. The core formulation containing highest amount of Ac-Di-Sol® showed fast disintegration and fast release because of swellable disintegrant present in it. Ac-Di-Sol® is one of the best superdisintegrant having excellent disintegrating ability. It swells to a large when it come in contact with water to disintegrate tablets and has a fibrous nature that allows intra particulate as well as extra particulate wicking of water even at low concentration. The core formulations containing crosspovidone and it is water insoluble tablet disintegrant used at 2 to 5% concentration in tablet prepared by direct compression either wet or dry granulation methods. It rapidly exhibits high capillary activity and pronounced hydration capacity with little tendency of crosspovidone strongly influence disintegration of tablets. Larger particles provide a faster disintegration than smaller particles. Crosspovidone can also be used as a solubility enhancer with the technique of co evaporation. It can be also used to enhance the solubility of poorly soluble drugs. The drug is adsorbed on to crosspovidone in the presence of a suitable solvent and the solvent is then evaporated. This technique results in faster dissolution rate. newlineFrom the results it can be concluded that, different drug release mechanisms were observed by incorporating different polymers and excipients into the outer shell and different core composition. By deeping the knowledge of polymeric materials behavior in dosage forms and, in particular, their application in the dry coating of different core compositions like those proposed in this study, a safe and more accurate targeting of the drug from dosage forms can be achieved.