Development of Nanocarriers for Topical Delivery of Drug in Skin Disease

Abstract

The aim of this thesis was to develop a suitable topical lipid based dosage form of tazarotene, an antipsoriatic drug. The development of this formulation should overcome all its contraindications caused by the conventional dosage form over the sensitive skin surface of application. The dosage form development should improve the physicochemical and/or biopharmaceutical properties of tazarotene as desired for the drug on skin application. The main objective of the present study was to formulate an improved topical delivery system for dermal targeting of tazarotene. It is an attempt to, enhance the dermal retention of tazarotene and prevent its ready degradation on skin to its active form and to minimize skin irritation. To conclude, the interesting and impressive results obtained in the studies, are encouraging with respect to the development a promising delivery system for psoriasis treatment which will overcome all the problems of the drug tazarotene to deliver it topically in an effective manner with all ease to the patient after administration. The results put together demonstrate the achievement of the objectives of the study and successful accomplishment of the envisaged research. Tazarotene in novel formulation with controlled delivery is a thrust area of drug research which is not explored and is most sought for. Success of any product formulation research lies in its commercialization potential which is very high with solid lipid nanoparticles due to ease of scaling up of manufacture and the stable nature of the final formulation once included into a gel. The gel formulation was selected at it produces soothing effect of gel and the irritation due to exposure of ingredients is less since they are of generally recognized as safe status. Compared to synthetic formulations the lipid based drug delivery system like SLN are not very costly and the targeted population can afford in ease the cost of treatment. newline