Evaluation of Ayabringaraja Paanidham in the Management of Veluppu Noi

Abstract

Anaemia being a global public health issue has made a major impact on socio-economic development in both developing and developed countries. Since, the management of anaemia is a decisive issue worldwide, WHO encourages traditional medicines to establish a safe, effective and economic drug for the same. Siddha system includes many herbal and herbo-mineral formulations which are therapeutically used in anaemia. Among these, iron based formulations play an important role. Aya Bringaraja Paanidham (ABP) is one such formulation which has a unique combination of herbs and processed iron. newlineThe aim of this study was to evaluate the safety and efficacy of a Siddha herbomineral drug, Aya Bringaraja Paanidham (ABP) in the management of Veluppu noi (Anaemia). The primary objective to achieve this aim was to evaluate the pharmacological and clinical efficacy of ABP. In addition, secondary objective was to determine the toxicity of ABP in experimental animal models and human participants. To reach these objectives, the basic objective was to prepare the trial formulation, ABP and to standardize the same using modern techniques. The Physio-chemical analysis of the trial drug Aya Bhringaraja Paanidham has revealed its safety through the results observed found to be with in normal limits as per WHO standards. The results of Toxicity studies (Acute and Sub-Acute) were found safe thereby ensuring the safety of trial drug in experimental animal models. The Pharmacological screening has shown that the trial drug has Erythropoeitic and Hepatoprotective activity in experimental animal models. The Clinical Trial has shown that ABP is effective, safe and cost effective in treating IDA patients. The improvements in the diagnostic features, both clinical and hematological were significant with no adverse alterations in Liver and Renal function tests. This study has validated the traditional formulation ABP for its safety and efficacy in human participants. The trial drug ABP is found to be economical and safe in the management of Veluppu Noi.