Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/334920
Title: | Development Characterization of a Nanomaterial and its Impact in Biomedical Applications |
Researcher: | Charu Bharti |
Guide(s): | Sharma, Sharestha and Gupta, Pankaj |
Keywords: | Pharmaceutical chemistry Pharmaceutics |
University: | K.R. Mangalam Univeristy, Gurgaon |
Completed Date: | 2021 |
Abstract: | The current investigation is focused on formulation, optimisation and characterisation of polymeric based nanomaterial. Nitazoxanide (NTZ) loaded polymeric nanoparticles were prepared by homogenisation technique using Eudragit RL100 as a polymer matrix and Poly vinyl alcohol (PVA) as a cross linking agent. NTZ was used as a model drug and investigated for preformulation parameters along with excipients, identification of concentration for optimization, selection of independent (X) and dependent (Y) variables and characterisation of optimised formulation. Polymeric nanoparticles were obtained after optimization using 33 factorial design by Box Behnken Design expert (BBD). The role and influence of key process variables i.e. concentration of polymer, concentration of cross linking agent and speed of rotation of homogeniser at their respective three different levels for the optimisation of formulation. The synthesised optimised polymeric nanoparticles were further characterised by dynamic light scattering (DLS) for its particle size (137.11nm), PDI (0.180) and zeta potential (33.4 mV) while X-ray diffraction (XRD) was used to justify the amorphous and crystalline nature of drug and excipients. Transmission electron microscopy (TEM) further revealed surface geometry of these nanoparticles being spherical in shape, drug entrapment efficiency (%DEE) was found to be 81.89% and in vitro release studies showed sustained drug release effect. The antimicrobial activity against Pseudomonas aeruginosa, Streptococcus mutans and Escherichia coli was also determined. Keywords: Polymeric nanoparticles, Box Behnken Design expert, Nitazoxanide, Dynamic light scattering, antimicrobial activity. newline |
Pagination: | xvi, 152 |
URI: | http://hdl.handle.net/10603/334920 |
Appears in Departments: | Department of Pharmaceutical Sciences |
Files in This Item:
File | Description | Size | Format | |
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10. paper published.pdf | Attached File | 6.6 MB | Adobe PDF | View/Open |
11. biography of student.pdf | 523.95 kB | Adobe PDF | View/Open | |
12. biography of supervisor.pdf | 627.07 kB | Adobe PDF | View/Open | |
13. biography of co-supervisor.pdf | 517.04 kB | Adobe PDF | View/Open | |
14. plag certificate.pdf | 525.39 kB | Adobe PDF | View/Open | |
1. title.pdf | 52.21 kB | Adobe PDF | View/Open | |
2. certificate.pdf | 167.68 kB | Adobe PDF | View/Open | |
3. preliminary pages.pdf | 2.21 MB | Adobe PDF | View/Open | |
4. chapter 1 (introduction).pdf | 760.53 kB | Adobe PDF | View/Open | |
5. chapter 2 (literature review ).pdf | 735.42 kB | Adobe PDF | View/Open | |
6. chapter 3 (research methodology).pdf | 807.64 kB | Adobe PDF | View/Open | |
7. chapter 4 (results & discussions).pdf | 4.05 MB | Adobe PDF | View/Open | |
80_recommendation.pdf | 458.43 kB | Adobe PDF | View/Open | |
8. chapter 5 (conclusions and future scope of work).pdf | 373.34 kB | Adobe PDF | View/Open | |
9. references.pdf | 796.44 kB | Adobe PDF | View/Open |
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