Nanofibers for biomedical applications

Abstract

In present nano-scaled materials have been investigated with remarkable interest greater than before due to many advantages, such as enhanced physical and chemical properties with preference in alteration of properties to the desired fields of applications. Tissue engineering is a favourable alternative approach to treat the malfunction or loss of defects in issues caused due to trauma or diseased tissue without the restrictions of current therapies, especially the bone marrow studies targets to repair the damaged tissue by replacement of cells or bring together bioactive factors in a biocompatible scaffold. Scaffolds made-up of bioactive materials and biodegradable polymers composed with living cell are so often used in tissue engineering. Scaffolds are support structures used in tissue engineering to rovide the three dimensional growth of cells. Electrospun nanofibrous scaffolds can be tailored in accordance with the purpose of their use. Such hybrid nanofibers scaffolds play an important role in providing a suitable environment to the cells, which ultimately results in their better attachment, roliferation, and differentiation. Poly- -caprolactone (PCL) is a bioresorbable scaffold (BRS) polymer obtained by the polymerization of polyester with an open loop structure of -caprolactone with promising applications for cartilage and bone repair especially for tissue engineering applications. It is a well-known iocompatible polymer with properties such as good thermal stability, mechanical strength and biodegradable. Calcium Hydroxyapatite[ ( ) ( ) ] is a bioactive bioceramic materials which possesses bioactivity and biocompatibility. It has similar composition as human bone and teeth. newline