Electroanalysis of antibiotics on metal oxide nanoparticles modified glassy carbon electrode

Abstract

Electro-analytical techniques can easily solve many problems of pharmaceutical interest with a high degree of accuracy, precision, sensitivity, and selectivity employing this approach. Some of the most useful electro analytical techniques are based on the concept of continuously changing the applied potentials to the electrode-solution interface and the resulting measured current. Electrochemical techniques are powerful and versatile analytical techniques that offer high sensitivity, accuracy, and precision as well as large linear dynamic range, with relatively low-cost instrumentation. After developing more sensitive pulse methods, the electroanalytical studies are more regularly used on many applications like drug analysis in their dosage forms and especially in biological samples. Three antibiotics such as cefotaxime, cephalexin and cefuroxime were studied on glassy carbon electrode and modified electrode. The compounds are evaluated with pH effect on cyclic voltammetry, chronocoulometry, controlled potential coulometry. Among the pH between 1.0 and 13.0 the best medium was selected through trial and error methods. The results of the electrochemical techniques, especially voltammetry, have gained steadily an importance during the study. The redox mechanism ofcompounds also studied. Nowadays the electrode surface is very important for these studies. Three types of nanomaterial modified electrode like nickel oxide (NiO/GCE), copper oxide (CuO/GCE) and zinc oxide (ZnO/GCE) were used for complete analysis. Electroanalytical technique of differential pulse stripping voltammetry was employed for determination of drugs. newline