Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/332651
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dc.date.accessioned2021-07-20T04:54:17Z-
dc.date.available2021-07-20T04:54:17Z-
dc.identifier.urihttp://hdl.handle.net/10603/332651-
dc.description.abstractThe present thesis deals with the investigation carried out on the development of multiple-unit oral formulations for colon-specific drug delivery formulations with the objective of the release of API in the colonic region of GIT. The first chapter of the thesis gives a brief account on anatomy, physiology, the condition, prevalence of colon. The different strategies applied in formulating oral colonic drug delivery system was been discussed. The use of polymetha methacrylate in the system. Literature review of the prior investigation and developments for the delivery system is being mentioned. The second chapter deals with the scope and detailed objectives along with the plan of work. The detailed proposal of carrying the project is described. The pellets were formulated into capsules and tablets with emphasis to carry the API to the colonic region. The third chapter gives the details on the materials and methods of the study. The preformulation study related with organoleptic properties of API and polymers, development of in vitro dissolution method and compatibility studies by using DSC for the formulation. The experimental technique extrusion and spheronization used in the formulation of pellets, coating of pellets, characterization of pellets physically, in vitro and in vivo study are described in this chapter. The fourth chapter deals with the results inferred with the study and its discussions. A novel colonic drug delivery system was developed using multiple coating of aqueous polymethacrylates on core pellets containing API. These delivery system proved successful for site-specific colonic delivery. The delivery system can be easily manufactured on a large-scale in a reasonable processing from a regulatory viewpoint; all the ingredients comprising the delivery system are official. The thrust of this work was is the applicability of multiple coatings of polymethacrylates on formulated pellets for site-specific release in the ileocecal region and colon followed by sustained-release of a model API.
dc.format.extent156
dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleDevelopment of multiple unit oral formulations for colon specific drug delivery
dc.title.alternative
dc.creator.researcherRaju L
dc.subject.keywordcolon specific drug delivery
dc.subject.keywordDevelopment
dc.subject.keywordmultiple unit oral formulations
dc.description.note
dc.contributor.guideVijayan P
dc.publisher.placeChennai
dc.publisher.universityThe Tamil Nadu Dr. M.G.R. Medical University
dc.publisher.institutionDepartment of Pharmacy
dc.date.registered
dc.date.completed2010
dc.date.awarded
dc.format.dimensions
dc.format.accompanyingmaterialDVD
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Pharmacy

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01_title.pdfAttached File178.57 kBAdobe PDFView/Open
02_certificate.pdf99.26 kBAdobe PDFView/Open
03_preliminary pages.pdf270.08 kBAdobe PDFView/Open
04_chapter 1.pdf406.2 kBAdobe PDFView/Open
05_chapter 2.pdf45.71 kBAdobe PDFView/Open
06_chapter 3.pdf192.68 kBAdobe PDFView/Open
07_chapter 4.pdf1.54 MBAdobe PDFView/Open
08_references.pdf195.42 kBAdobe PDFView/Open
80_recommendation.pdf208.37 kBAdobe PDFView/Open


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