Studies on Immunological Biochemical and Genetic Aspects in Infertile Women with Premature Ovarian Failure and Risk Associated with Coronary Vascular Diseases

Abstract

The present study is undertaken to evaluate the immunological, biochemical and genetic aspects in infertile women with premature ovarian failure (POF) and its risk to coronary vascular diseases. In patients with POF, the role of hormones, auto antibodies and biochemical parameters were studied. Other risk factors such as inflammatory reactions, oxidative stress and somatic DNA damage were also evaluated. Life-style characters such as obesity, sedentary type occupation, irregular exercise and non-vegetarian diet have been reported as risk factors in POF. Family history of POF and mental stress also have played significant role in POF etiology. POF patients had an elevated body mass index (BMI) and abdominal circumference compared to control subjects that could be related to cardiovascular risk. Follicle stimulating hormone (FSH) and luteinizing hormone (LH) showed marked elevation along with deprivation of estradiol. Diabetes and Dylipidemia are reported in POF patients. The role of systemic lupus erythematosus was also evident in POF subjects. A similar observation was noted in inflammatory markers such as hs-CRP and fibrinogen, which is elevated in POF patients. Oxidative stress was found to be significantly high in POF subjects. The rise in inflammation and oxidative stress subject the POF subjects susceptible to DNA damage. The elevations of these parameters which are considered to be better risk markers of CVD suggest that, POF may predispose a woman for CVD. A substantial overall significant association of CVD risk factors in middle aged women (31-40 years) was observed as compared to other age groups suggesting a higher risk of developing cardiac events in this population. POF patients need more focus because it raises middle aged women s morbidity and all-cause mortality. Women with POF should be advised on how to reduce cardiovascular risk factors by monitoring to reduce the risk of premature death along with lipid reduction therapies.