An analysis of the nbn gene variants and its impact on breast cancer

Abstract

Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation among people. The current research on SNPs are focused finding out the congenital relationship of structural deviations with quantitative traits, genes associated with different heritable diseases, physical responsiveness of medicines to different medicines and susceptibility to environmental factors such as toxins, and risk of developing particular diseases such as cancer. NBN is a protein coding gene (Breast Cancer). Several cancer studies in the past have analyzed the change in amino acid substitution of NBN genes and their impact on various diseases. NBN is a protein coding gene (Breast Cancer). Nibrin is used to fix and rebuild the body from damages caused because of strand breaks (both singular and double) associated with protein nibrin. NBN gene was retrieved from dbSNP/NCBI database and investigated using computational SNP analysis tools. The encrypted region in SNPs (exonal SNPs) were analyzed using software tools, SIFT, Provean, Polyphen, INPS, SNAP and Phd-SNP. The 3 ends of SNPs in un-translated region were also investigated to determine the impact of binding. The association of NBN gene polymorphism leads to several diseases was studied. Four SNPs were predicted to be highly damaged in coding regions which are responsible for the diseases such as, Aplastic Anemia, Nijmegan breakage syndrome, Microsephaly normal intelligence, immune deficiency and hereditary cancer predisposing syndrome (clivar). newline