Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/332150
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dc.coverage.spatialAn analysis of the nbn gene variants and its impact on breast cancer
dc.date.accessioned2021-07-19T06:33:28Z-
dc.date.available2021-07-19T06:33:28Z-
dc.identifier.urihttp://hdl.handle.net/10603/332150-
dc.description.abstractSingle nucleotide polymorphisms (SNPs) are the most common type of genetic variation among people. The current research on SNPs are focused finding out the congenital relationship of structural deviations with quantitative traits, genes associated with different heritable diseases, physical responsiveness of medicines to different medicines and susceptibility to environmental factors such as toxins, and risk of developing particular diseases such as cancer. NBN is a protein coding gene (Breast Cancer). Several cancer studies in the past have analyzed the change in amino acid substitution of NBN genes and their impact on various diseases. NBN is a protein coding gene (Breast Cancer). Nibrin is used to fix and rebuild the body from damages caused because of strand breaks (both singular and double) associated with protein nibrin. NBN gene was retrieved from dbSNP/NCBI database and investigated using computational SNP analysis tools. The encrypted region in SNPs (exonal SNPs) were analyzed using software tools, SIFT, Provean, Polyphen, INPS, SNAP and Phd-SNP. The 3 ends of SNPs in un-translated region were also investigated to determine the impact of binding. The association of NBN gene polymorphism leads to several diseases was studied. Four SNPs were predicted to be highly damaged in coding regions which are responsible for the diseases such as, Aplastic Anemia, Nijmegan breakage syndrome, Microsephaly normal intelligence, immune deficiency and hereditary cancer predisposing syndrome (clivar). newline
dc.format.extentxv, 128p.
dc.languageEnglish
dc.relationp.109-127
dc.rightsuniversity
dc.titleAn analysis of the nbn gene variants and its impact on breast cancer
dc.title.alternative
dc.creator.researcherNithya P
dc.subject.keywordPhysical Sciences
dc.subject.keywordChemistry
dc.subject.keywordChemistry Applied
dc.subject.keywordbreast cancer
dc.subject.keywordnbn gene
dc.description.note
dc.contributor.guideChandrasekar A
dc.publisher.placeChennai
dc.publisher.universityAnna University
dc.publisher.institutionFaculty of Science and Humanities
dc.date.registered
dc.date.completed2020
dc.date.awarded2020
dc.format.dimensions21cm
dc.format.accompanyingmaterialNone
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Faculty of Science and Humanities

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02_certificates.pdf226.22 kBAdobe PDFView/Open
03_vivaproceedings.pdf372.52 kBAdobe PDFView/Open
04_bonafidecertificate.pdf219.88 kBAdobe PDFView/Open
05_abstracts.pdf1.06 MBAdobe PDFView/Open
06_acknowledgements.pdf288.8 kBAdobe PDFView/Open
07_contents.pdf1.09 MBAdobe PDFView/Open
08_listoftables.pdf980.36 kBAdobe PDFView/Open
09_listoffigures.pdf902.21 kBAdobe PDFView/Open
10_listofabbreviations.pdf1.09 MBAdobe PDFView/Open
11_chapter1.pdf1.17 MBAdobe PDFView/Open
12_chapter2.pdf1.1 MBAdobe PDFView/Open
13_chapter3.pdf1.23 MBAdobe PDFView/Open
14_chapter4.pdf2.35 MBAdobe PDFView/Open
15_chapter5.pdf993.36 kBAdobe PDFView/Open
16_conclusion.pdf993.36 kBAdobe PDFView/Open
17_references.pdf1.16 MBAdobe PDFView/Open
18_listofpublications.pdf986.22 kBAdobe PDFView/Open
80_recommendation.pdf77.45 kBAdobe PDFView/Open


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