Development and Screening of Isotretinoin Gel For The Treatment of Skin Problem Acne

Abstract

Acne vulgaris is a commonly diagnosed inflammatory skin condition newlinethat affects pediatric, young and adult patients. The object of the paper is newlineformulation development and evaluation of isotretinoin gel for the treatment of Acne newlinevulgaris. The isotretinoin based anti-acne gel was formulated using different newlinepolymers includes carbopol 940, carbopol 934 and carbopol 980. Disodium edetate newlineis used as chelating agents. The anti-acne gel was evaluated for solubility, drug newlinerelease, pH and drug interaction, in-vitro drug release through Franz diffusion cells, newlineacute skin irritation test and antibacterial test. The evaluation test was also compared newlinewith the marketed formulation of isotretinoin gel, that is, sortet gel. The antibacterial newlineand anti-acne activity of different formulations was determined by the modified agar newlinewell diffusion method in the culture of Propionibacterium acne. The optimized newlineformulation (F-IB) showed the highest spreadability (48.623 g/cm3 newline), in all newlineformulations and also have a high percentage of drug contents (97.2%). In-vitro newlinediffusion study suggested that F-IA, F-IC, F-IIA and F-IIB showed more diffusion, newlineand drug release from all the formulations, that is, 94.5%, 96.5%, 92.5% and 92.7% newlineas compared to sotret gel (94.2%). The antibacterial activity was studied on newlineanaerobic microorganism P. acne, compared with marketed sortet gel. Formulation newlinebatches have shown maximum zone of inhibition to P. acne below marketed newlineformulations and standard benzyl peroxide gel. The anti-acne gel of isotretinoin was newlinesuccessfully formulated and evaluated by different parameters. The results indicate newlinethat the active component, that is, isotretinoin is more effective when subjected to newlinegel formulations and produces effective anti-acne activity in the management of newlineAcne vulgaris newline