Biocompatible Superparamagnetic Ferrite Nanoparticles for Treatment of Cancer By Hyperthermia

Abstract

Rapid change of the nanoparticles magnetization in the vicinity of a human body temperature may be exploited to improve the performance of a number of biomedical applications. Apart from the use in self-controlled magnetic nanoparticles hyperthermia, where the controllably changed behavior of magnetization may prevent the living tissues from overheating and destroy cancer cells, it has been observed that the peculiar properties of ferrite nanoparticles leads to great influence on the development of biomedical applications for noninvasive temperature monitoring. Recent work in the area of magnetic hyperthermia for cancer treatment shows that this technique is very novel and working on the fact of non-linear magnetization response of superparamagnetic nanoparticles. Therefore, the understanding of heat loss mechanisms during this whole process of treatment is very important. Basically the magnetic energy is converted into heat energy that further help to attain the desirable hyperthermia range (42oC to 46oC) and that leads to depletion of surrounding (tissue/organ) medium. But, this demands sufficient and quantitative understanding of the behavior of nanoparticles. In our opinion, on the basis of our observations, the use of the approach defined in the present work is will likely to give escalation to the magnetic hyperthermia technique to design of novel superparamagnetic nanoparticles. However, magnetic nanoparticles for treatment of cancer have certain limitations. The challenge for the researchers towards the clinical trials is to achieve optimized temperature to avoid overheating of healthy tissues or organs for the longer duration of time under hyperthermia treatment. To overcome the above drawbacks, the present thesis is focus on synthesis and characterization of and#946;-NaFeO2 nanoparticles for cancer treatment via hyperthermia. This compounds possesses excellent chemical stability, no agglomeration, high magnetization, biocompatible, ease of synthesis, superparamagnetic, promising self-heating induction, high Curie s and blocking temperature. Their structural, morphological, composition analysis, optical, magnetic, hyperthermia studies has been done. In vitro cytotoxicity test on HeLa cell lines, have been performed in order to investigate their dose-dependent cytotoxicity.