Design Development and Optimization of Biotechnologically derived products as Liposphere by using suitable Colloidal Carriers

Abstract

In the recent years, it has been realized that complete drug therapy for an ailment does not rely on the development of new drugs alone. In this context, a promosing approach involves the development of suitable drug delivery systems. Numerous polymer based colloidal carriers have widely been studied as drug carriers in the field of drug delivery system. But the use of synthetic polymer matrix materials often goes along with detrimental effects on incorporated drug during manufacturing of the formulations or during the erosion of the polymers after application. Moreover, the degradation of polymer might possibly cause systemic toxic effects through the impairment of Reticulo Endothelial System or after phagocytosis of particles by human macrophages and granulocytes. Therefore, alternative carrier substances have been investigated; among them lipidic materials have garnered growing attention. Numerous lipid based delivery system such as liposomes, solid lipid nanoparticles, oily suspensions, sub micron lipid emulsions, lipid implants, lipospheres have been investigated for proteins and peptides. Lipospheres carrier systems has several advantages over other delivery systems, including emulsions, liposomes and microspheres, such as: Better physical stability, low cost of ingredients, ease of preparation and scale up, high dispersibility in an aqueous medium, high entrapment of hydrophobic drugs, controlled particle size and extended release of entrapped drug. Cefixime is the first member of what is generally termed the third generation orally active cephalosporins. These third generation cephalosporins are distinct from the older and#946;-lactam antibiotics in their intensive antibacterial activity against a wide range of gram-negative bacteria. Cefixime is freely soluble in methanol but has low aqueous which affects its rate of absorption, resulting in a low and variable oral bioavailability of about solubility and poor dissolution in gastric fluid 40-50%. It has been classified as biopharmaceutical classification system class II drug.