Design synthesis and characterisation flavanoid analogues and evaluation biodynamic properties

Abstract

The present study deals on naturally mimicking flavonoid analogues such as newlineflavones and flavanones were prepared by synthetic route for evaluation of their newlinebiodynamic properties. The first step in the scheme of synthesis was preparation of newlinechalcones by Claisen Schmidt condensation reaction between substituted newlineacetophenones and aromatic aldehydes in presence of base under the warm condition. newlineThe formed intermediate chalcone derivatives were further processed for two types of newlinereaction in the preparation of flavones and flavanone derivatives. newlineFrom which the study concludes that all newlinesynthesised compounds were posses significant results but the presence of electron newlinedonating group such as hydroxyl, methoxy, dimethyl amino and some heterocyclic newlinesubstituents such as thiophenyl and furyl group in the nucleus produced highly newlinesignificant result than the existing compounds. Hence the hybridised flavones (HF4-HF8) and flavanones (HFA3-HFA7) were found as lead moieties in the management of diabetes associated with free newlineradical scavenging role and against the inflammatory response. Even though these newlineresults suggest this study have not fulfilled in establishing the precise mechanism and newlineaction of this molecule, hence this study should be proceed through evaluation of newlinevarious enzyme inhibitory action. The detailed study on molecular biology and newlinechronic toxicity studies along with screening of therapeutic application of this drug in newlinedifferent models were helpful for development of potent drug in the effective newlinemanagement of diabetic mellitus. newline