Screening for Anti Inflammatory Analgesic and Wound Healing Potential of Some Selected Medicinal Plants

Abstract

In the present research work, three individual drug extracts e.g. Atrocarpus heterophyllus Linn fruits, Pongamia glabra leaves and Piper nigrum fruits has been obtained by using soxhlet extraction method. The extract of three herbal drugs were evaluated for the anaemic and diabetic wound healing activity by excision, and incision wound healing model and also evaluated for additional analgesic and anti-inflammatory activity. Three different plant extract i.e. AHEM (100, 200 and 400 mg/kg), PGEF (100, 200 and 400 mg/kg) and PNEP (100, 200 and 400 mg/kg) concentration has selected. newline All the results indicated, AHEM (200 and 400 mg/kg) was shown the enhanced wound healing potential as compare to PGEF (100 and 200 mg/kg) and PNEP (100 and 200 mg/kg) concentration. The herbal extract of Atrocarpus heterophyllus fruits, Pongamia glabra leaves and Piper nigrum fruits showed marked reduction in wound area in comparison to control group when examined for wound healing activity by topical application in albino rats. newline Anti-inflammatory activity of all the three extracts were investigated using carrageenan induced rat paw edema model and cotton pellet induced granuloma model in Wistar rats. In carrageenan induced rat paw edema model, AHEM (200 and 400 mg/kg) dose dependently showed significant decrease in paw volume. PGEF(100 and 200 mg/kg) and PNEP (100 and 200mg/kg) was found to be less active in decreasing paw volume. In cotton pellet induced granuloma model, AHEM (200 and 400mg/kg) showed significant inhibition of granuloma formation as compare to PGEF (100 and 200mg/kg) and PNEP (100 and 200mg/kg). newline Analgesic activity of the three extracts was investigated using hot-plate test and acetic acid induced writhing model in Swiss albino mice. In hot plate test, all the extract didn t show increase in pain latency, while standard drug pentazocine showed significant increase in pain latency. In acetic acid induced writhing model, AHEM (200, 400 mg/kg) showed significant decrease in number of writhings than PGEF (100, 200