Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/330458
Title: | Cross linked biopolymeric beads used as a pharmaceutical carrier for oral controlled drug delivery system |
Researcher: | Priyanka Sinha |
Guide(s): | Ubaidulla U |
Keywords: | Cross linked biopolymeric beads oral controlled drug delivery system pharmaceutical carrier |
University: | The Tamil Nadu Dr. M.G.R. Medical University |
Completed Date: | 2018 |
Abstract: | The physiology of the gastrointestinal tract presents serious barriers and challenges to oral drug delivery. The wide intra- and intersubject variability of gastrointestinal transit time is an important factor that can have a significant influence on drug bioavailability. Mucoadhesive formulations can increase and harmonize the passage time through the gastrointestinal tract, with the potential benefit of more reproducible drug bioavailability. This effect can be enhanced by using multiparticulate drug delivery system instead of single-unit dosage forms as the gastrointestinal transit of the formers is more reproducible and predictable. The present study aims to investigate the efficacy of the novel biopolymeric complex multiparticulate system consisting of chitosan succinate (CS) and sodium alginate (SA) and carboxy methyl cellulose (CMC) as a pharmaceutical carrier showed promising attributes to be considered to deliver the drug at the targeted site of colon carcinogenetic cells. By improving the site specific delivery, it holds a greater possibility to decrease the dose frequency and lower side effects. newline |
Pagination: | 1-223 |
URI: | http://hdl.handle.net/10603/330458 |
Appears in Departments: | Department of Pharmacy |
Files in This Item:
File | Description | Size | Format | |
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01_title.pdf | Attached File | 100.23 kB | Adobe PDF | View/Open |
02_contents.pdf | 58.79 kB | Adobe PDF | View/Open | |
03_acknowledgement.pdf | 63.62 kB | Adobe PDF | View/Open | |
04_certificate.pdf | 108.26 kB | Adobe PDF | View/Open | |
05_list of tables.pdf | 63.94 kB | Adobe PDF | View/Open | |
06_list of figures.pdf | 144.56 kB | Adobe PDF | View/Open | |
07_chapter 1.pdf | 947.1 kB | Adobe PDF | View/Open | |
08_chapter 2.pdf | 604.1 kB | Adobe PDF | View/Open | |
09_chapter 3.pdf | 366.44 kB | Adobe PDF | View/Open | |
10_chapter 4.pdf | 346.11 kB | Adobe PDF | View/Open | |
11_chapter 5.pdf | 414.35 kB | Adobe PDF | View/Open | |
12_chapter 6.pdf | 1.52 MB | Adobe PDF | View/Open | |
13_chapter 7.pdf | 1.63 MB | Adobe PDF | View/Open | |
14_chapter 8.pdf | 1.81 MB | Adobe PDF | View/Open | |
15_chapter 9.pdf | 277.89 kB | Adobe PDF | View/Open | |
16_chapter 10.pdf | 463.84 kB | Adobe PDF | View/Open | |
80_recommendation.pdf | 295.84 kB | Adobe PDF | View/Open |
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