Design synthesis and anticancer activity of some novel pyrimidine derivatives as protein kinase target

Abstract

Sixteen compounds, Eight in each series of 13(a-h) and 14(a-h) were designed and predicted for their anticancer activity targeting Protein kinase receptor through computational studies. This is achieved by screening Physicochemical parameters, Bioactivity score, Prediction of activity spectrum of the substance and finally by molecular docking studies. Out of the sixteen compounds 13f, 13h, 14f and 14h that showed better binding energy compared to the standard drug Sunitinib was further selected for synthesis . All the four compounds were synthesized. The synthesized compounds were purified by recrystallization. The purity of the compounds were checked by Thin Layer Chromatography and by using Melting Point determination by open capillary tube method. In the present work, Computational approach was used to select the appropriate Leads for targeting a particular receptor involved in Cancer progression Selection of Leads was done spending less cost and time. To conclude, the above findings clearly demonstrated that the compounds 13f and 14h is a good anticancer agent that can be developed as a potential protein kinase inhibitor. IMPACT OF THE WORK and#61656; Compounds 13f and 14h can be developed as a novel lead for anticancer agents targeting VEGFR-2 that plays an important role in tumor angiogenesis. Above compounds can be further carried out for In vivo anticancer activity. Compounds 13f and 14h has a scope to be an attractive candidates for further investment and licensing with an industry. Even though several research proves that Protein Kinases are potential targets for anticancer treatment only few studies and drug are developed targeting this receptors . Hence, an attempt made to explore a new lead targeting Protein Kinase receptor may open a new avenue towards fulfilling a significant medical need. newline