Role of specific inflammatory markers and adipokines in relation to insulin resistance and beta cell function

Abstract

Prospective diabetes prevention studies can provide valuable information on the early pathogenesis of diabetes. The primary aim of this study was to understand the association of selected biomarkers; visfatin, resistin, fetuin-A and chemerin with pancreatic and#946;-cell function and insulin resistance in persons at high risk for development of type 2 diabetes (T2DM). The selected samples were a subcohort of a previous large-scale primary prevention programme conducted in southern India. In the multiple logistic regression analysis resistin did not newlineshow an association with the conversion to diabetes. Fetuin-A was positively correlated with newlineinsulin resistance, plasma glucose, serum visfatin and waist circumference. The multivariate analysis showed that the highest category of fetuin-A tertiles to be associated newlinewith increased risk of developing T2DM (OR: 22.48 [95%CI 6.52-77.54]; plt0.0001). A mean newlinevalue of 236.2µg/ml can predict incident diabetes with a sensitivity of 71% and specificity of newline75%, plt0.0001. The area under the curve was 0.80±SE 0.04 (95% CI 0.73-0.88). Serum newlinechemerin correlated with body mass index and body fat components. But its concentration was newlinenot associated with the conversion of prediabetes to T2DM. newlineAmong the selected adipokines, visfatin and fetuin-A were found to be predictive of future newlinediabetes in the Asian Indian population. This was probably related to its association with insulin newlineresistance. newline newline