1. Shodhganga@INFLIBNET
  2. M S Ramaiah University of Applied Sciences
  3. Department of Pedodontics and Preventive Dentistry
Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/329980
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dc.date.accessioned2021-06-30T10:38:25Z-
dc.date.available2021-06-30T10:38:25Z-
dc.identifier.urihttp://hdl.handle.net/10603/329980-
dc.description.abstractThe present study was conducted to evaluate anticariogenic and remineralizationpotential of developed cocoa varnish using in-vitro and software simulation studies. Catechins, Epicatechin, and Theobromine bioactive compounds were isolated from Cocoa beans using Preparative High-PerformanceLiquid Chromatography(HPLC). The UV-Vis Spectroscopy, Fourier-Transform Infrared Spectroscopy(FTIR), Mass Spectroscopy (MS), and Nuclear Magnetic Resonance Spectroscopy (NMR) wasused for characterization of the isolated bioactive compounds. The biological activity of isolated bioactive compounds against selected Streptococcus mutanstargets and pharmacokineticsproperties such asAbsorption, Distribution, Metabolism, Excretion, and Toxicity(ADME/T) were assessed using in-silico molecular docking study. The cytotoxic effects of the isolated bioactive compounds were assessed using in-vitro cell-based MTT assay. These isolated compounds were formulated in to five different cocoa varnishes.
dc.format.extent
dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleEvaluation of Anticariogenic and Remineralization Potential of the Cocoa Varnish Through In Vitro and Software Simulation Studies
dc.title.alternative
dc.creator.researcherPushpalatha,C
dc.subject.keywordClinical Medicine
dc.subject.keywordClinical Pre Clinical and Health
dc.subject.keywordDentistry Oral Surgery and Medicine
dc.description.note
dc.contributor.guideSwaroop Hegde, Deveswaran R
dc.publisher.placeBengaluru
dc.publisher.universityM S Ramaiah University of Applied Sciences
dc.publisher.institutionDepartment of Pedodontics and Preventive Dentistry
dc.date.registered2014
dc.date.completed2020
dc.date.awarded2020
dc.format.dimensions
dc.format.accompanyingmaterialDVD
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Pedodontics and Preventive Dentistry

Files in This Item:
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01_title page.pdfAttached File477.6 kBAdobe PDFView/Open
02_preliminary pages.pdf1.07 MBAdobe PDFView/Open
03_chapter 1.pdf1.65 MBAdobe PDFView/Open
04_chapter 2.pdf2.05 MBAdobe PDFView/Open
05_chapter 3.pdf2.74 MBAdobe PDFView/Open
06_chapter 4.pdf2.79 MBAdobe PDFView/Open
07_chapter 5.pdf1.51 MBAdobe PDFView/Open
08_chapter 6.pdf2.69 MBAdobe PDFView/Open
09_chapter 7.pdf532.01 kBAdobe PDFView/Open
10_references.pdf1.01 MBAdobe PDFView/Open
80_recommendation.pdf1.01 MBAdobe PDFView/Open
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