Effect of HAART on hematological profile and oxidative stress in HIV naïve patients

Abstract

newline Background:-The people with HIV/AIDs have various haematological derangements and also show oxidative stress. Aim:- is to study haematological parameters and oxidative parameters before and after HAART (3 months) in HIV positive individuals and further to study there correlation with CD4 count. Methodology:-After permission from IEC and consent, haematological parameters(Hb, WBC, blood indices, platelets, and CD4 count estimated in 100 HIV positive individuals before and after HAART. Oxidative parameters (Total antioxidant concentration(TAC),Nitric-oxide(NO),VitE) were done in 50 individuals(from above 100) before and after HAART. Correlation of haematological profile and oxidative parameters with CD4 was assessed. Result:-Anaemia is the most common blood disorder seen in HIV naïve individuals. There is highly significant increase in Hb level after 3 month of HAART(Plt0.0001) and highly significant positive correlation with CD4 count after treatment(plt0,0001). There is highly significant increase in MCV and CD4 count after HAART(Plt0.0001).There is highly significant increase in TAC and NO(plt0,0001) and showing highly significant and positive correlation with CD4 count(plt0.0001) after treatment. There is significant increase in vit E level(plt0.01) and positive correlation with CD4 count(plt0.01) after treatment. Conclusion:- Hb estimation should be done before and during treatment in HIV individuals, TAC estimation in HIV naïve may help to take early measures, to reduce oxidative stress and prevent progress of disease. Vitamin E and micronutrient supplementation may help to reduce oxidative stress and disease progression in HIV. newline newline