Nanoparticle Delivery System Of Anti Cancer Drugs

Abstract

newline The objective of this research was dose reduction and toxicity reduction. Dose newlinereduction: various anti-cancer drugs are very costly and their high dose increases cost. If newlinebioavailability is enhanced, the dose shall be reduced thereby the cost will also newlinedecrease. Dose reduction will reduce toxicity and the preparation will become more newlinetolerable. In this study the nanoparticles were developed by using modified method with newlinethe drug carboplatin which was later evaluated for stability, toxicity and therapeutic newlineefficacy using various in-vitro and in-vivo techniques like SRB assay. The resulting newlinedosage form was found to be more effective and less toxic than the marketed newlinepreparation of drug carboplatin which is an i.v. injection. As carboplatin is a platinum newlinecompound and has the biggest drawback of the toxic side effects, which makes the newlinechemotherapy less acceptable. But formulation of drug in form of nanoparticles side newlineeffects was minimized without harming the therapeutic efficacy. Anti-cancer agents, newlinehave a number of adverse side effects and high levels of toxicity e.g. hair loss due to the newlineeffects on hair follicles, anaemia, immune system impairment, and clotting problems, newlinereduction in the number of red cells, white cells, and platelets. newlineIn the present study development and evaluation of nanoparticles for cancer treatment newlinewas done so as to improve complications of side effects if anti cancer drugs carboplatin newlineand cisplatin. In the first experimental part, blank placebo nanoparticles were prepared newlineby using various standard and self modified methods using different polymers like PEG, newlineAlbumin, Gelatin, Eudragit® and Resomer® of various grades etc., to achieve nanosize. Which were then characterized. Later many polymers nanoparticles discarded, as newlinethe nanoparticles were either not formed properly or if prepared they are not of good newlinesize and stability. Eudragit® and Resomer® were found to be best best polymers. In newlinesecond part of experimentation drug cisplatin and carboplatin loaded nanoparticles were newlineprepared