analytical and bioanalytical method development and validation for the selected new pharmaceutical dosage form by hplc and lcmsms

Abstract

Pharmaceutical analysis plays a major role in the determination of drugs content in dosage forms and in biological matrices such as plasma, serum, urine, etc. Chromatographic techniques such as HPLC and LC-MS/MS plays a major role for drug quantification at low concentration in dosage form as well as in biological fluids. newlineThe goal of present study is to meet the demand of pharmaceutical industry by developing new suitable analytical and bio analytical methods. Hence the present work deals with simple, sensitive and selective analytical and bioanalytical method along with stability studies for the following methods by HPLC and LC-MS/MS. newline1. Bioanalytical method for Canagliflozin by LC-MS/MS newline2. Bioanalytical method for Dapagliflozin by LC-MS/MS newline3. Bioanalytical method for Ondansetron by LC-MS/MS newline4. Bioanalytical method for Metformin and Canagliflozin by HPLC newline5. Analytical method for Dapagliflozin and Saxagliptin by HPLC newline6. Analytical method for Metformin and Dapagliflozin by HPLC newline7. Analytical method for Metformin and Teneligliptin by HPLC newline8. Analytical method for Sofosbuvir and Velpatasvir by HPLC newlineIn view of current scenario in pharmaceutical industry, Bioanalysis plays a major role for new drug approval. So,Bioanalytical method by LC-MS/MS method were developed for the drugs such as canagliflozin, Dapagliflozin and Ondansetron etc newline newline