Metal Oxide Nanoparticles Catalyzed Organoboranes Syntheses and Reactivity Studies

Abstract

The work presented in the thesis entitled Metal Oxide Nanoparticles Catalyzed newlineOrganoboranes Syntheses and Reactivity Studies describes the synthesis of metal/metal newlineoxide nanoparticles and their utility in the C-B bond formation reaction. Chapter 1 includes newlinethe synthesis and applications of boronic acids and esters. In chapter 2 detailed progress in newlinethe field of recyclable catalyst systems, particularly metal and metal oxide nanoparticles newlinecatalyzed organoborane synthesis, has been described. newlineChapter 3 presents the first Fe2O3-nanoparticles catalyzed hydroboration of aromatic and newlinealiphatic aldehydes and ketones with HBpin (pin = OCMe2CMe2O). This process applies to a newlinebroad range of substrates with high functional group compatibility. Moreover, aldehydes are newlineselectively hydroborated over the cother reducible functional groups, such as ketone, nitrile, newlinehydroxide, alkene, amide, ester, nitro, and halides. newlineIn chapter 4 we illustrates a magnetically separable Cu nanocatalyst for the borylation of newlinealkyl halides with alkoxy diboron reagents, providing alkylboronic esters in high yields, with newlinebroad functional group tolerance under mild reaction conditions. The procedure is also newlineapplicable to the borylation of benzyl chlorides and bromides. newlineChapter 5 presents an efficient and recyclable Cu nano- -boration of newline-unsaturated carbonyl compounds with bis(pinacolato)diboron at room temperature. This newlineprotocol tolerated a variety of functional groups including electron-withdrawing and - newlinedonating groups. Remarkably, the catalyst could be recovered and reused for five runs newlinewithout any significant decrease in activity. newlineChapter 6 illustrates nano-ferrite-supported Cu-nanoparticles as an excellent catalyst for the newlinehydroboration of alkenes. This protocol is applicable to a range of substrates having diverse newlinefunctional groups. newlineIn chapter 7 we summarized all the findings illustrated in the previous chapters. We newlinedemonstrated that recyclable metal/metal oxide nanoparticles catalyzed syntheses of newlineorganoboronates provide ease way to achieve these derivatives. newline