Synthesis of cyclitols and their analogs from naturally occurring inositols

Abstract

The thesis entitled ‘Synthesis of cyclitols and their analogs from naturally occurring inositols’ consists of four chapters. The first chapter is a review of reactions wherein regioselectivity is affected by the influence of metal ions present in the reaction mixture. The second chapter describes the work done to study the effect of the alkali metal counter ion (sodium or lithium) in the base, on the regioselectivity during O-alkylation reactions of myo-inositol derivatives and the preparation of orthogonally protected myo-inositol orthoester derivatives. The third chapter illustrates of the use of orthogonally protected myo-inositol derivatives for the preparation of isomeric cyclitol derivatives. The fourth chapter presents the synthesis of valiolamine from myo-inositol, based on the results generated in the previous chapters.