Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/318259
Title: | Design synthesis and biological evaluation of triazole oxadiazole conjugates as potential candidates for the treatment of cognitive dysfunction |
Researcher: | Jain, Ankit |
Guide(s): | Piplani, Poonam |
Keywords: | Cognitive dysfunction Pharmaceutical Chemistry Pharmacy Triazole Oxadiazole |
University: | Panjab University |
Completed Date: | 2020 |
Abstract: | Acetylcholinesterase has been a promising target for the development of putative therapeutics against cognitive decline. The deleterious effect of oxidative stress on the learning and memory paradigms of an individual has also been well documented. In view of this, the present study demonstrates the design, synthesis and pharmacological evaluation of triazole-oxadiazole conjugates. Thirty novel hybrids have been synthesised by employing suitable synthetic procedures and characterized by various spectral and elemental techniques. Further these synthesised compounds were evaluated against behavioural alterations using step down passive avoidance and escape learning protocol at a dose of 0.5 mg/kg with reference to the standard, donepezil. All the synthesised compounds were evaluated for their in vitro acetylcholinesterase (AChE) inhibition at five different concentrations using mice brain homogenate as the source of the enzyme. Biochemical estimation of markers of oxidative stress (lipid peroxidation, superoxide dismutase, glutathione and catalase) has also been carried out to assess the role of synthesised molecules on the oxidative damage induced by scopolamine. newline |
Pagination: | vi, 203p. |
URI: | http://hdl.handle.net/10603/318259 |
Appears in Departments: | University Institute of Pharmaceutical Sciences |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
01_title.pdf | Attached File | 5.22 kB | Adobe PDF | View/Open |
02_correction form.pdf | 238.4 kB | Adobe PDF | View/Open | |
03_acknowledgement.pdf | 260.72 kB | Adobe PDF | View/Open | |
04_contents.pdf | 201.46 kB | Adobe PDF | View/Open | |
05_list of figures.pdf | 160.03 kB | Adobe PDF | View/Open | |
06_list of tables.pdf | 21.25 kB | Adobe PDF | View/Open | |
07_introduction.pdf | 370.02 kB | Adobe PDF | View/Open | |
08_literature review.pdf | 2.7 MB | Adobe PDF | View/Open | |
09_results and discussion.pdf | 2.79 MB | Adobe PDF | View/Open | |
10_summary and conclusion.pdf | 347.07 kB | Adobe PDF | View/Open | |
11_experimental.pdf | 923.15 kB | Adobe PDF | View/Open | |
12_references.pdf | 904.97 kB | Adobe PDF | View/Open | |
13_list of publications.pdf | 130.19 kB | Adobe PDF | View/Open | |
80_recommendation.pdf | 347.07 kB | Adobe PDF | View/Open |
Items in Shodhganga are licensed under Creative Commons Licence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0).
Altmetric Badge: