Molecular pathogenesis of enteropathogenic escherichia coli epec role of a surface marker in diagnosis and identification of a novel small molecule as a potential therapeutic agent

Abstract

Enteropathogenic Escherichia coli EPEC is one of the leading newlinecauses of childhood diarrhoea in developing countries EPEC is a noninvasive newlinepathogen that belongs to the class of Attaching and Effacing AE newlinepathogens It produces a localized adherence pattern on host cells causes newlinedisruptioneffacement of microvilli electrolyte loss and eventual cell death newlinedue to apoptosis The pathogenicity island called locus of enterocyte newlineeffacement LEE is required for the AE lesion formation LEE encodes the newlinetype III secreted proteins EspA B C D F and G Map bundle forming pili newlineBFP intimin and its receptor Tir Other nonLEE encoded proteins like newlineEspC EspG Glyceraldehyde 3phosphate dehydrogenase NleA and Cif also newlineplay a major role in EPEC pathogenesis newline newline newline