Analytical and Kinetic Studies of Some Antidepressant Drugs

Abstract

The present work deals with the first generation antidepressants TCAs drugs that is newlineimipramine ,desipramine and amitriptyline and some other drugs .This substances share a basic newlinechemical structure comprising a three ring compound and alkali amine side chain . The present newlinestudy also aim to reach such out come with micelle /mixed micelle, polymer /cyclodextrin with newlinefirst generation tricyclic antidepressant. The therapeutic action of a drug needs the confluence of newlinedifferent factor to occur. Molecular complexation in an artificial model system is an inversely newlinetools widely used in the interpretation of a number of biological mechanism .The fundament of newlineobjectives of the present work are newlinei) Development of analytical procedure for the determination of first generation newlineantidepressant drug such as amitriptyline etc newlineii) Reactivity of TCAs in micellar /mixed micellar media newlineiii) Molecular encapsulation with and#946;-cyclodextrin newlineiv) To study the reactivity of TCAs in polymer media newlinev) To analyze the rate kinetic data by different available micellar catalysis model newlinevi) To stabilized and elucidate the mechanism for the hydrolysis of first generation newlineTCAs newlinePresent study can serve as promising and useful starting point for the investigation of newlinechemical reactivity of TCAs in micellar media. A systematic and careful collection of newlinedata is necessary in order to observe and predict the underlying trend in the effects of newlinemicelles on the reaction mechanism. The entire experimental work, results and newlineconclusion have been presented in five chapters. newline