Synthesis characterization and biological activity evaluation of transition metal chelates of Pyridoxal derivatives

Abstract

Pyridoxal is one of the natural forms of vitamin B6. In the presence of metal ions, free pyridoxal can catalyze a variety of newlinemetabolic reactions such as transmination, decarboxylation and racemization of amino acids in which pyridoxal phosphate (PLP) being the physiologically active form of pyridoxal acts as a co-enzyme. Transition metal complexes play an important and diverse role in medicinal biochemistry. Schiff bases and their metal complexes newlinehave been known for their biological applications such as anti inflammatory, antipyretic, antidiabetic, analgesic, antibacterial, anticancer and anti-HIV activity. The hydrazoneschiff bases act as newlineexcellent chelating agents and the presence an additional functional newlinegroup like OH, NH or SH in the close vicinity to the azomethine group,theyform stable complex with five or six membered ring with the metal ion. Hydrazone moieties have been important due to their newlinediverse pharmacopial activities. Chelation therapy has been one of the applications useful to detoxify poisonous metals such as mercury, arsenic and lead by converting them into a soluble chemically inert form, mostly a chelate that can be excreted without any further interaction with the body. Pyridoxal isonicotinoyl hydrazone (PIH) a tridentate chelator, has high newlineiron chelation ability in vitro and in vivo, with high selectivity. Many novel iron chelating agents of pyridoxal isonicotinoyl hydrazone class demonstrate biological activities such as antitumor, anticancerand antimalarialactivity and applications like cytotoxicity, cell proliferation differentiation and immunology.