Total synthesis of tetrahydroisoquinoline alkaloids and novel synthetic methodologies

Abstract

we have developed a novel strategy for the efficient synthesis of newlinebenzo[b]cyclopenta[f]pyrrolo[1,2-d][1,4]diazepin-11(9H)-one derivatives through a newlinecascade of aza-Piancatelli reaction followed by Friedel-Crafts alkylation. This is the newlinefirst report on the synthesis of biologically relevant cis-fused pyrrolobenzodiazepinone newlinescaffolds by means of aza-Piancatelli rearrangement newline