Stereoselective Synthesis of Solifenacin Sitagliptin using tert Butanesulfinamide and Development of Novel Methodologies for the synthesis of Benzoxazines Benzothiazines and Rutaecarpine derivatives

Abstract

Many researchers from around the world have contributed innovative and newlineoften practicall methods using tert-butanesulfinamide (4) as an extremely versatile newlinereagent for the robust and general asymmetric synthesis of diverse classes of amine newlinecontaining compounds. The ready availability of tertbutanesulfinamide in large quantities newlineat low cost, the robustness and generality of many of its methods, and the prominence of newlineamine-containing compounds in drugs, agrochemicals, and naturally occurring materials newlineensures that tertbutanesulfinamide based methods will continue to be some of the most newlineextensively used methods in the synthesis. newline