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http://hdl.handle.net/10603/31182
Title: | Analysis of somatic cell mutations at the Glycophorin a locus in human erythrocytes |
Researcher: | Maddaly Ravi |
Guide(s): | Paul, Solomon F D |
Keywords: | Glycophorin Human erythrocytes Human Genetics |
Upload Date: | 19-Dec-2014 |
University: | Sri Ramachandra University |
Completed Date: | January, 2005 |
Abstract: | Introduction: Dose evaluation of exposed humans to radiation becomes necessary newlineafter exposure. Such a dose evaluation can be done by biological dosimetric methods newlineof which increased somatic cell mutant frequencies in exposed individuals can be a newlinereliable index [1]. Biological dosimetry has an important role to play in assessing the newlinecumulative radiation exposure of persons working with radiation and also in newlineestimating the true dose received during accidents involving external and internal newlineexposure. Biodosimetric methods include cytogenetic, immunological and mutational assays [2]. The need for biodosimetry is essential for caliberating the actual dose received to a biological system where other conventional forms of dosimetry are unavailable. Even in the presence of other dosimetric tools such as Thermo Luminescent Devices (TLDs) etc, biological dosimetry gives actual doses apart from an indication of the extent of damage caused by such damages. This becomes all the more important newlinewith the current situations such as space programmes and dirty bombs. There are currently many advancing methods for measuring somatic mutations and new opportunities for biological dosimetry of high-risk groups. An evaluation of such mutations becomes all the more important, as such mutations can be possible predictors of cancer risk [3]. Somatic mutations can now be measured in several human genes. The genes currently used include the hemoglobin (Hb) genes on chromosome 11 and 16, the glycophorin A (GPA) gene on chromosome 4, the newlinehypoxanthine-guanine phosphoribosyltransferase (HPRT) gene on the Xchromosome, the HLA genes on the chromosome 6 and the T-cell receptor (TCR) genes on chromosomes 7 and 14. Of the various assays for somatic mutations, only GPA and HPRT have been studied sufficiently to have reliable databases. newline |
Pagination: | 131p. |
URI: | http://hdl.handle.net/10603/31182 |
Appears in Departments: | Department of Human Genetics |
Files in This Item:
File | Description | Size | Format | |
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01_title.pdf | Attached File | 87.19 kB | Adobe PDF | View/Open |
02_certificate & declaration.pdf | 359.99 kB | Adobe PDF | View/Open | |
03_acknoledgements.pdf | 9.58 kB | Adobe PDF | View/Open | |
04_contents.pdf | 310.72 kB | Adobe PDF | View/Open | |
05_abstract.pdf | 125.67 kB | Adobe PDF | View/Open | |
06_chapter_1.pdf | 1.64 MB | Adobe PDF | View/Open | |
07_chapter_2.pdf | 167.02 kB | Adobe PDF | View/Open | |
08_chapter_3.pdf | 147.34 kB | Adobe PDF | View/Open | |
09_chapter_4.pdf | 266.54 kB | Adobe PDF | View/Open | |
10_chapter_5.pdf | 992.65 kB | Adobe PDF | View/Open | |
11_chapter_6.pdf | 268.27 kB | Adobe PDF | View/Open | |
12_chapter_7.pdf | 366.22 kB | Adobe PDF | View/Open | |
13_chapter_8.pdf | 73.46 kB | Adobe PDF | View/Open | |
14_chapter_9.pdf | 288.19 kB | Adobe PDF | View/Open | |
15_conclusion.pdf | 92.43 kB | Adobe PDF | View/Open | |
16_references.pdf | 383.94 kB | Adobe PDF | View/Open | |
17_publications.pdf | 62.84 kB | Adobe PDF | View/Open |
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