Etiopathogenesis of Ovarian Dysfunction Using Anthropometric Measurements Life Style Factors And Various Biomarkers

Abstract

The reproductive period of women from menarche to menopause is normally characterized by eumenorrhea and pathologically characterized by oiligomenorrhea and oligomenorrheic with polycystic ovarian syndrome (PCOS). The phenotypic expression of the above conditions is the result of interaction between the variables based on genotype with the impact of environmental factors. So the objective of the study is to explore the role of biomarkers, life style factors and anthropometric measurement with ovarian dysfunction. In order to identify the Etiopathogensis of ovarian dysfunction, after getting the institutional ethical committee clearance and informed consent from the participants, this work was divided in to 3 phases. PHASE I: To compare the life style factors, menarche age, menstrual cycle history, BMI, religion, nutritional habit and socioeconomic status in the adolescent age group. PHASE II: The biomarkers related to ovarian dysfunction were assessed between eumenorrheic, oligomenorrheic and PCOS adolescent and middle aged women. PHASE III: A comparative study was done to know the difference in the anthropometric measurement of the new born babies of normal mother and PCOS mother. newlinePhase I study reasons that menstrual abnormalities is hereditarily decided, the Phase II studies shows compensatory physiological variations in various ovarian dysfunction and the Phase III of this investigation reasons that phenotype for PCOS is expressed in neonatal intrauterine life itself. The etiopathogenesis of ovarian dysfunction is phenotypic output of bifactorial interaction between genotype and lifestyle factors with time related conceptual dysphysiological mechanism. newline CONCLUSION newline The etiopathogenesis of ovarian dysfunction is the phenotypic output of factorial interaction between genotype and lifestyle factors with time related conceptual dysphysiological mechanism. Phase 1 of this study concludes that menstrual irregularities is genetically determined and also alleviate the role of lifestyle factors in influencing the pathogenesis of PCOS. Phase II establishes the time dependence and compensatory physiological abnormalities using clinical biomarkers. PCOS, an ill-defined symptom complex needs its due attention. As ethnicity plays an important role in this symptom complex, there is a greater need to know the characteristics of the same in different populations. Imbalance of different hormonal functions can affect ovarian homeostasis resulting in anovulation, which will manifest as PCOS. The Phase III of this study concludes that phenotype for PCOS is expressed in neonatal life itself. newline newline