Investigations on Some Plants for the Management of Type 2 Diabetes

Abstract

Diabetes Mellitus (DM) is the metabolic disease with abnormal glucose homeostasis, due to defects in secretion or action of insulin. It has high prevalence globally and showed potentially morbid conditions and has become prime medical concern. Animal models play a vital role in conceptualizing these types of diseases. Diabetes in experimental animals develops either by using surgical, chemical, genetic method or by spontaneously and illustrates numerous clinical features or associated phenotypes of the diseases. For induction of diabetes in the experimental animals, Streptozotocin (STZ) is a widely employed chemical. In the experimental animals Nicotinamide play a protective role against destruction of pancreatic- cells in STZ induced diabetes model. Other findings of the study recommended that the Clematis heynei and Solanum virginianum is also produced beneficial effects in complications of the diabetes mellitus and obesity. The present study findings indicated that the usefulness of the Clematis heynei and Solanum virginianum streptozotocin nicotinamide -induced diabetic rats. Our study suggested that Clematis heynei and Solanum virginianum dose-dependently produced antidiabetic activity. In this study might be helpful to understand the role of Clematis heynei and Solanum virginianum in the clinical treatment of Diabetes Mellitus. The Clematis heynei and Solanum virginianum has also seems have potent hypolipidemic activity, which lowers the cholesterol, triglyceride, total proteins and increasing high-density lipoproteins levels. The mechanism has pointed towards, inhibiting cholesterol and triglyceride synthesis. Our study indicates the role of antioxidant activities of Clematis heynei and Solanum virginianum and active constituents play a role in preventing diabetic complications and antidiabetic activity of Clematis heynei and Solanum virginianum at 200 mg/kg of the dose was found to be more effective than 100 mg/kg of dose, its produced effects dose-dependently.. newline newline