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http://hdl.handle.net/10603/309269
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DC Field | Value | Language |
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dc.coverage.spatial | ||
dc.date.accessioned | 2020-12-16T09:55:21Z | - |
dc.date.available | 2020-12-16T09:55:21Z | - |
dc.identifier.uri | http://hdl.handle.net/10603/309269 | - |
dc.description.abstract | newline Majority of the infectious diseases along with those perpetuated by the drug newlineresistant pathogens take up second position in the list of leading causes of death newlineworldwide [1]. Due to the continual emergence and re- emergence of new and newlinealready reported diseases, respectively, there is constant concern regarding health newlineissues worldwide. According to a report by WHO, (1999) [2], total 53.9 million newlinedeaths were reported in year 1998, cardiovascular diseases were responsible for newlinenearly 31 % of deaths , a quarter of deaths (25%) were by infectious diseases, around newline13 % were result of various types of cancers, 11 % were due to the injuries caused to newlinepatient, 9 % deaths are caused by respiratory or digestive diseases whereas the newlineremaining 11 % deaths were due to other diseases including diseases from maternal newlinepedigree. A report in 2009 mentioned [3] that around 20% of the diseases are newlineoutcome of the infections originated due to bacteria, viral elements and parasites. newlineAmong bacteria, H. pylori was the foremost bacterium to be linked to a human newlinecancer, and after almost 20 years of its discovery, in 1994, the International Agency newlinefor Research on Cancer (IARC) classified H. pylori as a Classand#8208;I carcinogen [4] and newlinedeclared that H. pylori infected individuals have at least six fold greater risk of newlinedeveloping gastric cancer (GC) than those not carrying the infection [5]. newlineHelicobacter pylori, formerly known as Campylobacter pylori, has newlinemorphological dimensions as 3 µm long and 0.5 µm in diameter. It is a Gramnegative, micro-aerophilic bacteria that is part of the gastric microbiota in over 50% newlineof population worldwide [6, 7]. H. pylori is flagellated rod like bacterium with newlinesomewhat helical orientation [7]. It is highly motile due to lophotrichous (multiple newlinepolar) flagella [8, 9]. This organism is genotypically positive for enzymes like newlineurease, catalase and oxidase. Most of the H. pylori strains harbour additional newlinevirulence factors like Vac A and Cag A, evolved as arsenal to affect host cell newlinesignalling pathways. Phylo | |
dc.format.extent | ||
dc.language | English | |
dc.relation | ||
dc.rights | self | |
dc.title | Structural and mechanistic investigations of histone like dna binding protein of helicobacter pylori | |
dc.title.alternative | ||
dc.creator.researcher | Nancy Jaiswal | |
dc.subject.keyword | Engineering | |
dc.subject.keyword | Engineering and Technology | |
dc.subject.keyword | Engineering Multidisciplinary | |
dc.description.note | ||
dc.contributor.guide | Dinesh Kumar | |
dc.publisher.place | Lucknow | |
dc.publisher.university | Dr. A.P.J. Abdul Kalam Technical University | |
dc.publisher.institution | dean PG Studies and Research | |
dc.date.registered | 2015 | |
dc.date.completed | 2019 | |
dc.date.awarded | 2019 | |
dc.format.dimensions | ||
dc.format.accompanyingmaterial | DVD | |
dc.source.university | University | |
dc.type.degree | Ph.D. | |
Appears in Departments: | dean PG Studies and Research |
Files in This Item:
File | Description | Size | Format | |
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80_recommendation.pdf | Attached File | 4.45 MB | Adobe PDF | View/Open |
certificate.pdf | 409.71 kB | Adobe PDF | View/Open | |
chapter_1.pdf | 2.28 MB | Adobe PDF | View/Open | |
chapter_2.pdf | 668.72 kB | Adobe PDF | View/Open | |
chapter_3.pdf | 1.61 MB | Adobe PDF | View/Open | |
chapter_4.pdf | 1.12 MB | Adobe PDF | View/Open | |
chapter_5.pdf | 2.52 MB | Adobe PDF | View/Open | |
chapter_6.pdf | 1.05 MB | Adobe PDF | View/Open | |
chapter_7.pdf | 1.74 MB | Adobe PDF | View/Open | |
prelimnary.pdf | 564.19 kB | Adobe PDF | View/Open | |
title.pdf | 178.88 kB | Adobe PDF | View/Open |
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