Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/309269
Title: | Structural and mechanistic investigations of histone like dna binding protein of helicobacter pylori |
Researcher: | Nancy Jaiswal |
Guide(s): | Dinesh Kumar |
Keywords: | Engineering Engineering and Technology Engineering Multidisciplinary |
University: | Dr. A.P.J. Abdul Kalam Technical University |
Completed Date: | 2019 |
Abstract: | newline Majority of the infectious diseases along with those perpetuated by the drug newlineresistant pathogens take up second position in the list of leading causes of death newlineworldwide [1]. Due to the continual emergence and re- emergence of new and newlinealready reported diseases, respectively, there is constant concern regarding health newlineissues worldwide. According to a report by WHO, (1999) [2], total 53.9 million newlinedeaths were reported in year 1998, cardiovascular diseases were responsible for newlinenearly 31 % of deaths , a quarter of deaths (25%) were by infectious diseases, around newline13 % were result of various types of cancers, 11 % were due to the injuries caused to newlinepatient, 9 % deaths are caused by respiratory or digestive diseases whereas the newlineremaining 11 % deaths were due to other diseases including diseases from maternal newlinepedigree. A report in 2009 mentioned [3] that around 20% of the diseases are newlineoutcome of the infections originated due to bacteria, viral elements and parasites. newlineAmong bacteria, H. pylori was the foremost bacterium to be linked to a human newlinecancer, and after almost 20 years of its discovery, in 1994, the International Agency newlinefor Research on Cancer (IARC) classified H. pylori as a Classand#8208;I carcinogen [4] and newlinedeclared that H. pylori infected individuals have at least six fold greater risk of newlinedeveloping gastric cancer (GC) than those not carrying the infection [5]. newlineHelicobacter pylori, formerly known as Campylobacter pylori, has newlinemorphological dimensions as 3 µm long and 0.5 µm in diameter. It is a Gramnegative, micro-aerophilic bacteria that is part of the gastric microbiota in over 50% newlineof population worldwide [6, 7]. H. pylori is flagellated rod like bacterium with newlinesomewhat helical orientation [7]. It is highly motile due to lophotrichous (multiple newlinepolar) flagella [8, 9]. This organism is genotypically positive for enzymes like newlineurease, catalase and oxidase. Most of the H. pylori strains harbour additional newlinevirulence factors like Vac A and Cag A, evolved as arsenal to affect host cell newlinesignalling pathways. Phylo |
Pagination: | |
URI: | http://hdl.handle.net/10603/309269 |
Appears in Departments: | dean PG Studies and Research |
Files in This Item:
File | Description | Size | Format | |
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80_recommendation.pdf | Attached File | 4.45 MB | Adobe PDF | View/Open |
certificate.pdf | 409.71 kB | Adobe PDF | View/Open | |
chapter_1.pdf | 2.28 MB | Adobe PDF | View/Open | |
chapter_2.pdf | 668.72 kB | Adobe PDF | View/Open | |
chapter_3.pdf | 1.61 MB | Adobe PDF | View/Open | |
chapter_4.pdf | 1.12 MB | Adobe PDF | View/Open | |
chapter_5.pdf | 2.52 MB | Adobe PDF | View/Open | |
chapter_6.pdf | 1.05 MB | Adobe PDF | View/Open | |
chapter_7.pdf | 1.74 MB | Adobe PDF | View/Open | |
prelimnary.pdf | 564.19 kB | Adobe PDF | View/Open | |
title.pdf | 178.88 kB | Adobe PDF | View/Open |
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