A comparative study on Vangeshwara Rasa and Swarna vanga w s r to Pharmaceutical Analytical and Experimental

Abstract

ABSTRACT newline newlineTitle: A Comparative study on Vangeshwara rasa and Swarnavanga w s r to Pharmaceutical, Analytical and Experimental . newline newlineBackground newlineHuman era has always witnessed innumerable never ending diseases and their paved the way for placing on the table of therapeutics chapters on indigenous Herbo-Mineral/Metallic medicines. Toxicology is the study of adverse effects of chemicals on living organisms. The potential changes brought about by these compounds (be it organic or inorganic anything) can be judged by way of studies comprising certain physiological hematological biochemical and histopathological assessments since they any molecular level changes would be vividly displayed only by these battery of tests. Vangeshwara rasa and Swarnavanga are prepared by Kupipakwa method. newline newlineObjectives: To update review, Preparation, Physico-chemical analysis and Experimental study of Vangeshwara rasa and Swarnavanga newline newlineMaterials and Methods newline newlinePharmaceutical study newlineIt reveals Hingula Satvapatana and Shodhana of Parada, Vanga, Gandhaka and Navasadara, along with preparation of Vangeshwara rasa and Swarnavanga by Kupipakwa method. newlineAnalytical Study newlinePhysical and chemical tests were carried out by gravimetric, volumetric, XRD, XRF, NPST methods and particle size analysis by Laser diffraction method. newlineExperimental Study newline To perform acute and sub acute toxicity evaluation of Swarnavanga and Vangeshwara rasa as per OECD guidelines 425(Limit test), 401(Acute Oral Toxicity), 407(Sub Acute Oral Toxicity). An attempt to evaluate possible mortality and morbidity amongst the animals through bio chemical and histo pathological assessment was made. newline newlineResults newlineThe acute toxicity profile of Vangeshwara rasa and Swarnavanga is alike and shows the dose dependent response; but the sub acute toxicity of Swarnavanga at all dosage levels are inferior to the lowest dose of Vangeshwara rasa in haematological, hepatic and renal parameters. The histo pathological examination reveals mild to moderate inflammatory and necrotic change in target organs like liver