Effect of Iron Deprivation on Drug Resistance Of Mycobacterium Tuberculosis

Abstract

Tuberculosis (TB) is a second most cause of death after HIV (Saraceni et al. 2008). It is a communicable disease. It is caused by Mycobacterium tuberculosis (MTB) which is an obligate intracellular parasite that infects lung and colonizes the alveolar macrophages of the immune system. To decline the consequences of the infections novel interventions were explored from that time, but the first success was obtained in the first half of the 20th century. Development and identification of effective antibacterial activity of sulfonamides, penicillin and streptomycin followed by other antimicrobials drugs having a wide range of activity, was believed to be very hopeful without validation that bacterial infections were controlled satisfactorily and they would be eliminated. Unfortunately, the improper use of antibiotics and chemotherapeutics leads to the development of a resistance against widely used drugs, e.g. newlineStaphylococcus aureus resistance to methicillin (Lakhundi and Zhang 2018) enterococci or Gram-negative bacilli against and#946;-lactum antibiotics. Similar situation for the TB infection and the infection caused by various other mycobacterial species was observed. Subsequently, after the introduction of efficient antimycobacterial agent such as, streptomycin, para- aminosalicylic acid, isoniazid and cycloserine TB was unconsidered being a cruel threat regardless of its newlineconsequence; it was strongly assumed that TB would be completely eliminated in a short period. Despite of all these available drugs the resistance was developed against antituberculous (anti- newlineTB) drugs and at present it is spreading in the more severe forms of multidrug- and extensively drug-resistance (MDR and XDR). Moreover, no satisfactory drug has been invented; probably this aim is unreachable. Therefore, new antimycobacterial agents to combat TB are on urgent newlinepriorities.