Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/304486
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dc.coverage.spatialZoology
dc.date.accessioned2020-10-28T05:25:08Z-
dc.date.available2020-10-28T05:25:08Z-
dc.identifier.urihttp://hdl.handle.net/10603/304486-
dc.description.abstractThe present research work has explored the mitigating potential of EGCG against arsenic induced oxidative stress mediated cellular and sub-cellular changes, genotoxicity, apoptosis and metabolic disturbances that formed the basis of malignant transformation in hepato-renal tissues of mice. Out of pre and post treatments of EGCG, pre treatments of EGCG (25 mg and 50 mg/kg b.wt.) effectively reduced arsenic bioaccumulation, ROS production, serum and metabolic marker levels, recuperated the disturbed biochemical and morphological alterations. EGCG pre treatments reduced the genotoxin burden, cellular apoptosis, prevented metabolic disturbances by regulating the disturbed glucose metabolism and inhibited the malignant transformation. Thus, this data confers EGCG to possess geno-protective, anti-apoptotic and glucoregulatory efficacy against arsenic induced genotoxic and metabolic disturbances. Hence, EGCG could be explored as a potential pharmacological candidate for drug designing against metal induced genotoxicity, metabolic perturbations and malignant transformation. newline
dc.format.extent269p.
dc.languageEnglish
dc.relation-
dc.rightsuniversity
dc.titleTargeting arsenic induced metabolic disturbances and genotoxicity its mitigation by epigallocatechin gallate EGCG to prevent malignant transformation
dc.title.alternative
dc.creator.researcherKaushal, Surbhi
dc.subject.keywordEGCG
dc.subject.keywordGenotoxicity
dc.subject.keywordMetabolic perturbations
dc.subject.keywordOxidative stress
dc.subject.keywordROS
dc.description.noteBibliography 208-269p.
dc.contributor.guideSharma, V. L. and Chopra, Mani
dc.publisher.placeChandigarh
dc.publisher.universityPanjab University
dc.publisher.institutionDepartment of Zoology
dc.date.registered2013
dc.date.completed2019
dc.date.awarded
dc.format.dimensions-
dc.format.accompanyingmaterialCD
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Zoology

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01_title.pdfAttached File80.92 kBAdobe PDFView/Open
02_certificate.pdf447.75 kBAdobe PDFView/Open
03_acknowledgement.pdf95.33 kBAdobe PDFView/Open
04_content.pdf208.74 kBAdobe PDFView/Open
05_list of tables.pdf36.05 kBAdobe PDFView/Open
06_list of figures.pdf294.95 kBAdobe PDFView/Open
07_abbreviations.pdf138.88 kBAdobe PDFView/Open
08_abstract.pdf54.63 kBAdobe PDFView/Open
09_chapter 1.pdf285.13 kBAdobe PDFView/Open
10_chapter 2.pdf1.12 MBAdobe PDFView/Open
11_chapter 3.pdf876.71 kBAdobe PDFView/Open
12_chapter 4.pdf9.64 MBAdobe PDFView/Open
13_chapter 5.pdf1.52 MBAdobe PDFView/Open
14_chapter 6.pdf327.14 kBAdobe PDFView/Open
15_bibliography.pdf762.45 kBAdobe PDFView/Open
80_recommendation.pdf327.14 kBAdobe PDFView/Open


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