Effect of turmeric on oncogenic factors associated with Helicobacter pylori in gastric cancer patients

Abstract

This thesis is mainly focused on inhibitory role of turmeric against oncogenic factors associated with Helicobacter pylori infection. The thesis comprises following studies: systematic reviews to ascertain of current knowledge, qualitative research to ascertain the pharmacological role of curcumin (a constituent of turmeric) against oncogenic factors (cagA and HER2) associated with H. pylori. and computational approaches to investigate the potentiality of curcumin in comparison to some conventional drugs (clarithromycin, amoxicillin, pantoprazole, and metronidazole) against CagA (cytotoxic associated gene A) oncoprotein. In addition to above, an interactive properties of curcumin biotransformed compounds with CagA oncoprotein were analyzed for revealing the inhibitory potential against CagA+ H. pylori. The samples (cancerous tissues and blood) from gastric cancer patients with different body weight and ages were collected from operation theater, Department of Surgical Oncology, IMS, BHU and all the experimental work were performed in laboratory, Department of Botany, BHU and data were compiled newline