Modulating Physicochemical Attributes of Pharmaceutical Co Crystals A Case Study of Drug Polymer Small Molecular Systems

Abstract

In the literature, pharmaceutical co-crystals of small molecular drugs are well established. The FDA guidelines recently described this compound class as similar to a new polymorph of API. Co-crystals are considered as alternatives to traditional solid forms of API. However, there has always been a demand for better dissolution and drug delivery for drugs that are poorly water-soluble. Recent development has explored complexes of drug-polymer crystalline inclusion to mitigate problems associated with low-soluble drugs. In addition, it is also suggested to have an advantage in modulating the physical property of the API by selecting the preferred type of polymer. newlineThis research aims to study the modulation of the physicochemical attributes of APIs through co-crystallization with polymer as a co-former. In the literature, particularly for pharmaceutical co-crystals, the role of the polymer as a co-former is not well studied newline